Saturday, December 10, 2022

Drug Dosage as per IP
Drug Dosage As Per IP

The Govt. of India has created a separate, dedicated, autonomous institution in the form of the Indian Pharmacopoeia Commission (IPC) to deal with matters relating to the timely publication of the Indian Pharmacopoeia (IP)

Indian Pharmacopoeia (IP) is the official book of standards for drugs included therein, in terms of the Second Schedule to the Drugs and Cosmetics Act, of 1940.

Drug dosages are given in the Indian Pharmacopoeia (IP). Let's have a look:

Click for more on IPC and IP

NAME OF DRUGINITIAL DOSEMAINTENANCE / REGULAR DOSE Parenteral DoseAcebutolol HCl "Antihypertensive: Initially, 400 mg once daily; increased after 2 weeks to 400 mg twice daily.Antianginal: Initially, 400 mg once daily or 200 mg twice daily; in severe angina, 300 mg thrice daily; maintenance dose, up to 1.2 gm daily. Asantiarrhythmic, 400 mg to 1.2 gm daily, in 2 to 3 divided doses." Acetazolamide500mg250mg/every 6 Hrs Activated Charcoal 50 gm Adrenaline  200-500mcg  sc or imAlbendazole Nematodal infestation 400mg, Allopurinol100mg Single Dose gradually increased to 300mg daily200 to 400 mg Daily in divided dosage Alpha-Amylase 200 to 500mg Alprazolam 250 to 500 mcg TDS Amantadine HCl 100 mg daily, increased to 200mg daily in 2 divided dosage Amikacin  Up to 1.5gm daily in 2 divided dosages by IM, slow IV or inf.

Amiloride HCl5 to 10 mg dailyMaximum 20 mg daily Aminocaproic Acid5 gm Orally  and by slow inf,1 to 1.25 gm every Hr. Not more than 30 gm per 24 Hr, Aminophylline 100 to 300 mg250 to 500 mgAmitriptyline HCl50 to 75 mg daily in divided doses50 to 100 mg daily in divided doses Ammonium Chloride 3 to 6 gm daily in divided doses Amodiaquine400 mg Weekly400 to 600 mg  daily for 3 days Amoxycillin Sodium  1 to 3gm daily in divided doses IM or IVAmoxycillin Trihydrate 750mg to 4.5gm daily in divided doses Amphotericin B Up to 200mg every 6 hrs.250mcg/Kg body weight daily. increased to 1mg daily or 1.5 mg per Kg on alternate daysAmpicillin 2 to 6 gm daily in divided doses 

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Ampicillin Sodium  1 to 3 gm of Ampicillin daily in divided doses im or ivAmpicillin Trihydrate 2 to 6 gm daily in divided doses Analgin 500mg to 3gm daily in divided doses Ascorbic Acid Prophylactic,25 to 75 mg daily;               therapeutic,not less than 250 mg daily,in divided doses Aspirin As anlgesic/ antipyretic ,300 to 600 mg four to six times a day;as antirheumatic, 1 to 2 gm four to six times a day,,upto 10 gm dailyasantithrombotic ,75mg daily Astemizole "Adults, 10 mg once daily upto 7 days.Children, 5 mg once daily upto 7 days."Atenolol 50 to 100 mg ,daily,in 1 or 2 doses Atropine Methonitrate For treatment of congenital hypertrophic pyloric stenosis in infants, 200 to 600 mcg half an hour before feeds. Atropine Sulphate400 to 600 mcg four to six times a day sc, im, or iv; as antidote to cholinesterase inhibitors by iv inj. 2 to 4 mg initially, followed by im inj. 2 mg repeated every 5 to 10 minutes.Anticholinergic,orally.250mcg to 2mg daily in single or divided doses400 to 600 mcg four to six times a day sc, im, or iv; as antidote to cholinesterase inhibitors by iv inj. 2 to 4 mg initially, followed by im inj. 2 mg repeated every 5 to 10 minutes.BCG Vaccine(Freeze Dried)  Prophylactic, ic inj. As a single dose, 0.1 ml

Beclomethasone Dipropionate By inhalation, Adult, 2 inhalations, each of 50 mcg, three or four times a day upto max. of 20 inhalations in 24 hrs                                    Child, 1 or 2 inhalations, each of 50 mcg, three or four times a day upto a max. Of 10 inhalations in 24 hrs. Belladonna Dry Extract 15 to 60 mg. Benzathine Penicillin Orally, 3 lake Units to 6 lake Units every 6 hrs.3 lake Units to 10 lake Units im                           Prophylactic, by im inj. 12 lake Units every 2 or 3 weeks.Benzhexol HCl.1 mgGradually increased to a usual maintenance dose of 5 to 15 mg daily in 3 to 4 divided doses. Benzylpenicillin Potassium  The equivalent of 1.2 to 2.4 gm of benzylpenicillin daily, in 4 divided doses by im or by slow iv or by infusion.Benzylpenicillin Sodium  The equivalent of 1.2 to 2.4 gm of benzylpenicillin daily, in 4 divided doses by im or by slow iv or by infusion.Betamethasone 0.5 to05 mg daily in divided doses. Betamethasone Sod. Phosphate  The equivalent of 0.5 to 5 mg of Betamethasone daily, in divided doses. Acute adrenal insufficiency, by iv or im inj., the equivalent of 10 to 80 mg of Betamethasone daily in divided doses.Bisacodyl 5 to 10 mg daily. Bismuth Subcarbonate 1 to 4 gm. 

Bleomycin Sulphate  By inj. The equivalent of 15 to 30 Units of Bleomycin weekly in divided doses.Bromhexane HCl. 8 to 16 mg three to four times daily. Bromocriptine Mesylate The equivalent of 2.5 to 20 mg of Bromocriptine daily in divided doses. Bupivacaine HCl  By infiltration anaesthesia, the equivalent of 2 mg of anhydrous Bupivacaine Hcl per Kg body weight.Buprenorphine HCl Sublingually, upto 400 mcg every 6 to 8 hrs.300 to 600 mcg every 6 to 8 hrs;im or slow iv;Busulphan2 to 4 mg dailyMaintenance dose, 0.5 to 2 mg daily. Caffeine 300 to 600 mg Calcium Carbonate 1 to 5 gm. Calcium Chloride 1 to 2 gm5 to 10 ml of 10 % w/v solution by slow ivCalcium Folinate  Upto 120 mg in divided doses over 12 to 24 hrs by im or iv inj. Or infusion followed by 12 to 15 mg im or 15 mg orally every 6 hrs for the next 48 hrs.

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Calcium Gluconate Upto 15 gm daily, in divided doses1 to 2 gm by im or slow iv Inj.Calcium Lactate Upto 8 gm daily, in divided doses. Calcium Levulinate  1 gm once a day, by im or iv. Inj.Calcium Pantothenate 10 to 100 mg daily, in divided doses Captopril12.5 to 50 mg twice dailyUsual maintenance dose, 25 mg twice daily, maximum, 50 mg twice daily. Carbamazepine200 mg dailyIncreasing to 1.2 gm daily, in divided doses, in accordance with the needs of the patient. Carbenicillin Sodium  By iv inj., the equivalent of 12 to 30 gm of Carbenicillin daily, in divided doses; by im inj., the equivalent of 4 to 8 gm of Carbenicillin daily, in divided doses.Carbenoxolone Sodium 300 mg daily, in divided doses for 1 week; subsequently, upto 150 mg daily, in divided doses. Carbidopa 10 to 25 mg in combination with Levadopa CarbimazoleControlling dose, 30 to 60 mg daily, in divided dosesMaintenance dose, 5 to 20 mg daily. 

Castor Oil 5 to 15 ml. Cefadroxil 500 mg to 2 gm daily, in divided doses. Cefazolin Sodium  1 to 4 gm daily in divided doses, by im or iv or infusion.Cefotaxime Sodium  "1 to 2 gm of Cefotaxime Every 8 to 12 hrs by im or iv Inj.; By infusion, 1 to 2 gm given over 20 to 60 minutes.For children, the equivalent of 100 to 150 mg of Cefotaxime per kg body weight daily in 2 to 4 divided doses increasing to 200 mg per kg of body weight daily, if necessary."Ceftazidime  1 to 2 gm, every 8 to 12 hrs, by im or slow iv or iv infusion.Cefuroxime Sodium 250 mg twice daily750 to 1.5 gm, every 6 to 8 hrs, by im or iv or iv infusion.Cephalexin 1 to 4 gm daily, in divided doses. Cephlorididine  1 to 4 gm daily, in divided doses, by iv, im or deep sc inj.Chlorambucil 100 to 200 mcg per kg of body weight daily for 4 to 8 weeks. Chloramphenicol Adult, 1.5 to 3 gm daily, in divided doses; for a child, 25 to 50 mg per kg of body weight daily, in divided doses. 

Chloramphenicol Palmitate Adult, the equivalent of 1.5 to 3 gm of Chloramphenicol daily, in divided doses; for a child, the equivalent of 25 to 50 mg of Chloramphenicol per kg of body weight daily, in divided doses. Chloramphenicol Sodium Succinate  The equivalent of 3 to 4 gm of Chloramphenicol daily, in divided doses, by iv inj.Chlorcalciferol "Rickets; not more than 800 units daily.For the treatment of rickets &osteomalacia, 5000 to 50000 Units dailyFor the treatment of hypocalcaemia andhypoparathyroidism, 50000 to 200000 Units daily."200000 to 400000 Units by im inj.Chlordiazepoxide 10 to 100 mg daily, in divided doses. Chloroquine Phosphate "Prophylactic,300 mg once weekly; therapeutic,initial dose, 600 mg followed by a single dose of 300 mg after 6 to 8 hrs and then by a single dose of 300 mg daily for the next 2 to 4 days & inhepatic amoebiasis 600 mg daily for 5 to 7 days followed by 300 mg to 450 mg daily or twice a week for a week for 2 weeks or longerBy im inj. 160 to 200 mg repeated intervals of 12 hrs until oral therapy is possible as Antimalarial and in hepatic amoebiasisChloroquine Sulphate Prophylactic,300 mg once weekly; therapeutic,initial dose, 600 mg followed by a single dose of 300 mg after 6 to 8 hrs and then by a single dose of 300 mg daily for the next 2 to 4 days & inhepatic amoebiasis 600 mg daily for 5 to 7 days folloved by 300 mg to 450 mg daily or twice a week for a week for 2 weeks or longer"By im inj. 160 to 200 mg repeated intervals of 12 hrs until oral therapy is possible as Antimalarial and in hepatic amoebiasisChlorpheniramine Maleate 4 to 16 mg daily, in divided doses10 to 20 mg, by sc or im inj. Repeated if required; maximum 40 mg in 24 hrs. By slow iv inj. over 1 minute, 10 to 20 mg diluted in the syringe with 5 to 10 ml of blood.Chlorpromazine HCl As antipsychotic, 75 to 300 mg daily, in divided doses; As antiemetic, 10 to 25 mg every 4 to 6 hrs.As antipsychotic, by im inj. 25 to 50 mg. As antiemetic, by deep im inj. 25 mg initially followed by 25 to 50 mg every 3 to 4 hrs until necessary.Chlorpropamide 100 to 500 mg daily. Chlorthalidone 50 to 200 mg daily. 

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Cholera Vaccine  "For adults and children over 10 years, by sc inj., initial dose, 0.5 ml; second dose, 1.0 ml after an interval of 4 to 6 weeks.For children 2 to 10 years, initial dose 0.3 ml; second dose 0.3 ml.For children 1 to 2 years, initial dose, 0.2 ml; second dose 0.2ml."Chorionic Gonadotrophin  By im inj, 500 to 5000 units twice weekly or in accordance with the needs and response of the patient.Ciprofloxacin  100 to 200 mg twice daily by infusion.Ciprofloxacin HCl The equivalent of 250 to 750 mg of Ciprofloxacin twice daily. Cisplastin  By iv infusion, 15 to 20 mg per sq. m. of body surface daily for 5 days.ClofazimineFor leprosy, for previously untreated patients, 100 mg 3 times weekly;For sulphone- resistant patients, 100 mg 6 times weekly. For the suppression of lepra reactions, 200 mg daily. Clonidine HCl 50 to 100mcg thrice daily increased gradually according to the needs & response of the patient; maximum daily dose 1.2 mg.By slow iv inj., 150 to 300 mcg; maximum daily dose 750 mcg.Cloxacillin Sodium The equivalent of 500 mg of Cloxacillin every 6 hrs, at least 30 minutes before food;By im inj. 250 mg every 4 to 6 hrs; by slow iv inj. or by infusion, 500 mg every 4 to 6 hrs.Codeine Phosphate 30 to 60 mg every 4 hrs when necessary, to a maximum of 200 mg daily. Colchicine1 mgSubsequent doses, 500 mcg every two hrs. 

Colchicine & Probenecid Tabs Colchicine 1 mg & Probenecid, 250 mg twice daily after food. Concentrated Glyceryl TrinitrateSolution" Sublingually (as tablet), 300 mcg to 1 mg, repeated as required. Cortisone Acetate 25 to 37.5 mg daily, in divided dosesBy im inj. 50 to 400 mg daily, in single or divided doses.Cyanocobalamin  For treatment of megaloblastic anaemia, by im inj. 1 to 2 mg in divided doses, in the first week. Subsequent doses, 250 mcg weekly until the blood count is normal, maintenance dose, 250 mcg every 3 or 4 weeks.Cyclophosphamide 100 to 150 mg dailyBy iv inj. 100 to 150 mg daily.Cyclserine 500 mg to 1 gm daily, in divided doses. Cyproheptadine HCl 4 to 20 mg daily, in divided doses. Cytarabine  To be determined by the physician.Danazol 200 to 800 mg daily, in divided doses. Dapsone 100 mg daily. 

Dehydroemetine HCl  By deep im inj. 60 to 90 mg daily.Desferrioxamine Mesylate After gastric lavage, 5 to 10 gm in 50 to 100 ml of liquid;By im inj. 1 to 2 gm in 10 to 20 ml of Water for Inj. every 3 to 12 hrs; by continuous iv infusion, upto 15 mg per kg per hour with a maximum of 80 mg per kg in 24 hrs.Dexamethasone 500 mcg to 10 mg daily, in divided doses. Dexamethasone Sodium Phosphate  In the treatment of adrenal insufficiency, by im or slow iv or infusion, 0.5 to 10 mg. In shock, by iv inj, or infusion, 2 to 6 mg per kg body weight, repeated if necessary after 2 to 6 hrs. In cerebral oedema, by iv inj., 10 mg initially, then 4 mg by im inj. every 6 hrs as required for 2 to 10 days.Dextromethorphan HCl 10 to 30 mg every 4 to 8 hrs. Diazepam In anxiety states, 2 mg thrice daily, increased if necessary to 15 to 30 mg daily, in divided doses; in insomnia associated with anxiety, 5 to 15 mg at bedtimeBy im or slow iv inj. 10 mg repeated if necessary after 4 hrs.Diclofenac Sodium 25 to 75 mg.25 to 75 mg.Dicyclomine HCl 30 to 60 mg daily, in divided doses. Oral Solution is required to be diluted; the diluted solution should be freshly prepared. Dienoestrol In the treatment of menopausal symptoms, 500 mcg to 5 mg daily; in the treatment of prostate carcinoma and mammary carcinoma, 15 to 30 mg daily; for suppression of lactation, 15 mg thrice daily for 3 days, followed by 15 mg daily fir 6 days. Diethylcarbamazine Citrate 150 to 500 mg daily. 

Digoxin"For rapid digitalisation,1to 1.5 mg in divided doses over 24 hrs; for less urgent digitalisation,250 to 500mcg daily;For paediatric use, 10 to 35 mcg per kg body weight in 3 or 4 divided doses over 24 hrs followed by 4 to 10 mcg per kg body weight daily""Maintenance dose, 62.5 to 500 mcg daily.For paediatric  maintenance dose, 250 mcg once or twice daily."By iv infusion inj. 750 mcg to 1 mg.Diloxanide Furoate 1.5 gm daily, in divided doses. Diltiazem HCl30 to 60 mg thrice daily;Maximum 480 mg daily Diluted Isosorbide Dinitrate "Sublingually, 5 to 10 mg in angina;Orally, 30 to120 mg daily, in divided doses." Diluted pentaerythritol Tetranitrate The equivalent of 20 to 60 mg of pentaerythritol tetranitrate, 3 to 4 times daily. Dimercaprol  By im inj., 2 to 3mg per kg of body weight every 4 hrs during the first day and subsequently, in accordance with the needs of the patient.Dimethicone 40 to 100 mg, four times daily. Diphenhydramine HCl 50 to 200 mg daily, in divided doses. Diphenoxylate HCl 5 to 30 mg daily, in divided doses. Disodium Edetate  By iv inj. 50 mg per kg of body weight, upto a maximum of 3 gm per day.

Disulfiram500 mg as a single dose for 1 to 2 weeksMaintenance dose, 125 to 500 mg daily. Dothiepin HClInitially 75 mg daily, in divided doses,Increased gradually, as necessary, to 150 mg daily. Doxepin HClInitially, the equivalent of 75 mg of Doxipen daily,in divided dosesIncreased gradually to a maximum of 300 mg daily, in divided doses. Doxorubicin HCl  To be determined by the physician in accordance with the needs of the patient.Doxycycline HClThe equivalent of 200 mg of Doxycycline on the first dayFollowed by 100 mg daily. D-Panthenol 250 to 500 mg. Dydrogesterone 10 mg twice daily. Emetine HCl  By sc or im inj. 30 to 60 mg daily.Enalapril MaleateInitial, 2.5 to 5 mg dailyMaintenance dose, 10 to 20 mg daily; maximum 40 mg daily. Ephedrine 15 to 60 mg. 

Ergocalciferol "Rickets; not more than 800 units daily.For the treatment of rickets & osteomalacia, 5000 to 50000 Units dailyFor the treatment of hypocalcaemia and hypoparathyroidism, 50000 to 200000 Units daily."200000 to 400000 Units by im inj.Ergometrine Maleate 250 mcg to 1 mg;By im inj. 200 to 500 mcg; by iv inj. 100 to 500 mcg.Ergotamine Tartrate 1 to 2 mg ;By sc or im inj. 250 to 500 mcg.Erythromycin 1 to 2 gm daily, in divided doses. Erythromycin Estolate 1 to 2 gm daily, in divided doses. Erythromycin Stearate 1 to 2 gm daily, in divided doses. Ethambutol HCl15 to 25 mg per kg of body weight daily, for 2 months,Followed by 15 mg per kg body weight daily. Ethinyloestradiol "For menopausal symptoms, 10 to 20 mcg daily continuously or for 21 days, repeated after 7 days, with a progestogen from day 17 to day 26 of cycle if uterus is intact.For primary amenorrhoea, 10 mcg on alternate days increasing to a maximum of 50 mcg daily continuously with a progestogen for the last 5 days of month." Ethionamide 250 to 375 mg daily, usually in a three drug regimen with Rifampicin And Dapsone Ethionamide 250 to 375 mg daily, usually in a three drug regimen with Rifampicin And Dapsone 

Ethosuximide"500 mg daily, in divided doses;For child, 50 to 125 mg twice daily;""Increasing to 2 gm as necessaryFor child, increasing to 250 mg, three to four times daily, as necessary." Ethyloestrenol 2 to 4 mg daily. Fenfluramine HClInitially, 20 mg morning & eveningIncreasing to a maximum of 80 mg twice daily, preferably half hour before breakfast. Ferrous Fumarate Prophylactic, 200 mg daily; therapeutic, 400 to 600 mg daily, in divided doses. Ferrous Gluconate Prophylactic, 600 mg daily; therapeutic, 1.2 to 1.8 gm daily, in divided doses. Ferrous Sulphate Prophylactic, 300 mg; therapeutic 600 to 900 mg daily in divided doses. Fludrocortisone Acetate In adrenocortcal insufficiency, 50 to 300 mcg daily. Fluphenazine Decanoate  By deep im inj. test dose 6.25 to 12.5 mg, thereafter 4 to 7 days 12.5 to 100 mg repeated as required.Fluphenazine HCl 1 to 2 mg twice daily, in anxiety states; 2.5 to 10 mg daily in 2 to 3 divided doses in schizophrenia & other psychosesBy im inj. 1.25 to 10 mg daily.Flurbiprophen 150 to 200 mg, daily in divided doses, increased in acute conditions to 300 mg daily. 

Folic Acid "In the treatment of megaloblastic anaemia associated with folic acid deficiency, 5 to 20 mg daily.In the prophylaxis of megaloblastic anaemia of , 200 to 500 mcg daily." Fortified Benzathine Penicillin Inj.  To be determined by the Physician in accordance with the needs of the patient.Frusemide In oedema, 20 to 40 mg daily; in oliguvria, 250 mg 4 to 6 times daily;By im or slow iv inj. 20 to 50 mgFurazolidone 400 mg daily, in divided doses. Fusidic Acid 500 mg to 1 gm every 8 hrs. Gentamicin Sulphate  By im or slow iv inj. over at least 3 minutes or by iv infusion, 2 to 5 mg per kg body weight daily, in divided doses.Glibenclamide 5 mg daily, adjusted according to response; maximum 15 mg daily, after food. Griseofulvin 500 mg to 1 gm daily, in divide doses. Guaiphenesin "Adult: 200 to 400 mg every four hrs;Child aged: 6 to 12 yrs, 100 to 200 mg every four hrs;Child: 2 to 6 yrs, 50 to 100 mg every four hrs."Gugulipid 500 mg, equivalent to 25 mg of gugulsterones, thrice daily. 

Haloperidol 1.5 to 20 mg daily, in divided doses;By im or iv inj. 2 to 10 mg.Heavy Magnesium Carbonate "As antacid; 300 to 600 mg;As laxative, 2 to 4 gm." Heavy Magnesium Oxide "As antacid; 300 to 600 mg;As laxative, 2 to 4 gm." Heparin Sodium  Prophylactic, by sc inj. 10000 to 15000 Units daily, in divided doses; therapeutic, by iv inj. 20000 to 50000 Units daily, in divided doses.Hyaluronidase  By sc or im, inj. 1500 Units either mixed with the inj. fluid or injected into the site before inj. is administered.Hydralazine HCl 25 to 50 mg twice daily;By slow iv inj. 5 to 20 mg over 20 minutes; may be repeated after about 30 minutes.Hydrochlorothiazide 25 to 100 mg. Hydrocortisone Adrenocortical insufficiency, 20 to 30 mg daily, in divided doses;By im inj. or by slow iv inj. or infusion, 100 to 500 mg, 3 to 4 times in 24 hrs or as required.Hydrocortisone Acetate  By intra- articular inj. or local infiltration, 5 to 50 mg.Hydrocortisone Hemisuccinate  By iv inj., the equivalent of 100 to 500 mg of Hydrocortisone 3 to 4 times in 24 hrs or as required.

Hydroxocobalamin  In the treatment of megaloblastic anaemia, by im inj.
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