Storage conditions of drugs
Picture: Pixabay
Storage conditions and limit
Storage ConditionLimitRoom Temperature 20° to 25°Cool Storage Condition8° to 15°Cold Storage condition2° to 8°Fridge Storage condition-4° to 2°
List of Refrigerated Drugs and Medicines
Drugs/medicines that are required to be kept in the refrigerator are called refrigerated drugs/medicines.
The temperature of the refrigerator should be in the range of 2C to 8C.
This temperature is required for maintaining stability and potency throughout the drug's life.
These drugs/medicines are very sensitive in nature and require some extra care while manufacturing, transportation, stocking, prescribing, etc.
There are some other drugs that are required to be stored at temperatures of -15C to -20C.
These drugs/medicines are covered under Schedule C of the Drug and Cosmetic Act & Rules, 1940.
The storage conditions are to be mentioned on the labels of the drugs/medicines.
The list of refrigerated drugs is as follows:
- Sera
- Serum proteins
- Vaccines.
- Toxins
- Antigen
- Antitoxins
- Neo-arsphenamine and analogous substances are used for the specific treatment of infectious diseases.
- Insulin
- Pituitary (Posterior Lobe) Extract
- Adrenaline and Solutions of Salts of Adrenaline
- Specific Antibiotics and preparations (Parenterals and Non-Parenterals)
- Bacteriophages
- Ophthalmic preparations
- Sterile Disposable Devices for single use only
- Some plant extracts like digitalis, ergotamine etc
Definitions of Storage Conditions As Per IP 96
1. COLD: Any temperature not exceeding 8°C and usually between 2°C to 8°C. A refrigerator is a cold place in which the temperature is maintained thermostatically between 2°C to 8°C.
2. COOL: Any temperature between 8°C and 25°C. An article, for which storage in a cool place is directed may alternately, be stored in a refrigerator unless otherwise specified in the individual monograph.
3. ROOM TEMPERATURE: The temperature prevailing in a working area.
4. WARM: Any temperature between 30°C and 40°C.
5. EXCESSIVE HEAT: Any temperature above 40°C.
6. LIGHT RESISTANT CONTAINERS: A light-resistant container protects the content from the effect of actinic light by virtue of the specific properties of the material of which it is made.
7. WELL-CLOSED CONTAINER: A well-closed container protects the contents from contamination by extraneous liquid and from loss under normal conditions of handling, shipment, storage, and distribution.
Storage conditions of different drugs as per IP
1. In a Frozen State:
Ceftazidime Inj
2° to 8° C:
Antisera
Biphasic Isophane Insulin
Inj
BCG Vaccine
Carbenicillin Sodium Inj.
Carboprost Tromethamine Inj.
USP
Desferrioxamine Mesylate
Inj.
Dilzem™ Inj.
Dinoprostone Gel
Ergometrine Maleate Inj.
Gas-Gangrene Antitoxin
(Oedematiens)
Gas-Gangrene Antitoxin
(Perfringes)
Gas-Gangrene Antitoxin
(Septicum)
Hepatitis B Virus Vaccine (H
B Vac™ Enivac HB™ Engerrix B™
Heppacine-B™
Shanvac-B™)
Human Normal Immunoglobulin
Protamine Sulphate Inj.
Rabies Anti-serum-Equine
Rabies Immuno Globulin
(Human) EP
Rabies Vaccine Human (Neural
Tissue)
Rabies Vaccine, Human (Cell
Culture)
Recombinant Streptokinase
(r-Streptokinase) Inj. 1,500,000 IU
Rho (D) Immune Globulin
(Human) 50µg, 150µg, 300µg
Rubell Vaccine Live BP
Sandoglobulin™
Schick Control
Schick Test Toxin
Scorpion Venom Antiserum
Snake Venom Antiserum
Soluble Insulin Inj.
Streptokinase Inj.
Succinylcholine Chloride
Inj.
Tetanus Immunoglobulin BP
(Human)
Tetanus Vaccine (Adsorbed)
Typhoid Paratyphoid A
Vaccine
Typhoid Vaccine Oral
Typhoid Vaccine
Typhus Vaccine
Vaccines
Vasopressin Inj.
Vinblastine Sulphate Inj.
Vincristine Sulphate Inj.
Yellow Fever Vaccine, Live
3. Below 10° C:
Japanese Encephalitis
Vaccine, Human (Mouse Brain)
Methylprednisolone Acetate
Inj.
4. At a temp. Not exceeding
20° C:
Chorionic Gonadotrophin Inj.
(Pubergen 2000 IU ™)
Urokinase™
5. Between 2° & 25° C:
Human Plasma Protein
Fraction
6. Between 20° & 30° C:
Mannitol Inj.
7. In a Refrigerator:
Velocite ™ & Pregcolor ™
Test Kits
8. 23° or below:
Desferrioxamine Inj.
9. Store below 30°:
Dobutamine Inj. USP 50 mg/ml
Propofol Inj.™
10. Store in Cool Place:
Heparin Inj.
Morphine Inj.
11. To Be Stored Below 25°
C:
Cefotaxime Sodium Inj.
Cefuroxime Sodium Inj.
Dopamine Hydrochloride Inj.
USP
Enoxaparin Sodium Inj.
Human Chorionic
Gonadotrophin
Human Normal Albumin Soln
Menotrophin (hMG)
Meropenam Inj.
Naloxone Inj. 400mcg/ml
Nifedipine Sustained Release
Tab (Calcigard-10 Retard Tab™)
Urofolliotrophin (FSH) 75 IU
PRECAUTIONS 1. Should not be allowed to freezeAntisera Inj. Cortisone Acetate Inj. Fluorouracil Inj. Gas Gangrene Antitoxin (Oedematiens) Gas-Gangrene Antitoxin (Perfringens) Gas-Gangrene Antitoxin (Septicum) Hepatitis B Virus Vaccine Histaglobulin™ Insulins Methylprednisolone Acetate Inj. Mixed Gas-Gangrene Antitoxin Oxytocin Inj. Plague Vaccine Rabies Vaccine, Human (Neural Tissue) Scorpion Venom Antiserum Snake Venom Antiserum Succinylcholine Chloride Inj. Typhoid Paratyphoid A Vaccine Typhoid Vaccine Vaccines2. Avoid Long Exposure above 30° C Cyclophosphamide Inj.
Click to read other articles of the Author
Drug dosage
Banned drugs
Drug Dosage and Administration
Storage conditions of drugs
Import of drugs
Consumer Awareness
Procedure to obtain license for Medical Store / Pharmacy
How to start Jan Aushadhi Store: Procedure
Self audit of Medical Store :105 points
Record keeping for Medical Store / Pharmacy
How to change Pharmacist at Medical Store
Good storage practice of medicines at Medical Store
FAQs – on Medical Store / Pharmacy (Retail sale or Wholesale)
FAQs – on Mouthwash
FAQs – on Ear Drops
Difference between Sanitizer and Disinfectant
FAQs on Sanitizer, N95 Mask & Digital Thermometer
FAQs – On ‘Good Night’, ‘All Out’, ‘Hit’ and ‘Harpic’...
FAQs on Disinfectant (Part-1)FAQs – on Disinfectants (Part-2)
https://thehealthmaster.com/2022/12/07/storage-conditions-of-drugs/
No comments:
Post a Comment